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Prostate adenocarcinoma detected after high-grade prostatic intraepithelial neoplasia or atypical small acinar proliferation.

López JI

Department of Anatomic Pathology, Hospital de Basurto, Basque Country University (EHU/UPV), Bilbao, Spain. joseignacio.lopez@ehu.es

OBJECTIVE: To review specific histological variables in patients with prostate cancer who previously had diagnoses of high-grade prostatic intraepithelial neoplasia (HGPIN) and/or atypical small acinar proliferation (ASAP), compared with those who had no such diagnoses. PATIENTS AND METHODS: The histological characteristics of prostate cancers which were detected after a previous diagnosis of HGPIN and/or ASAP during 1998-2005 were investigated and correlated with the biopsies from patients with prostate cancer but with no such previous diagnoses. RESULTS: HGPIN was followed by prostate cancer on repeat biopsy in 16.8% of patients, and ASAP in 26.7%. The mean age of patients with HGPIN or ASAP was higher than in those with no such diagnoses (P < 0.001). Similarly, patients with these previous diagnoses had a lower Gleason score (P = 0.017 and <0.001, respectively) and lower tumour volume variables (fewer tumour foci, P = 0.033 and 0.041, respectively) and shorter cancer (P = 0.048 and 0.030) in core biopsies than those without. CONCLUSIONS: Patients with prostate cancer who had previous biopsies with HGPIN or ASAP were older and has lower grade- and volume-cancers than those who had not.

Published 5 November 2007 in BJU Int, 100(6): 1272-6.
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